Apply These Secret Techniques To Improve Pregnancy Loss And Chromosome Testing For Miscarriages

JeromyDelea 27 Mar , 2021 0 Comments Uncategorized

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is really quite common, with 10-25% of recognized pregnancies ending in miscarriage. When you have suffered a pregnancy loss or are currently in the process of having a miscarriage, you could be wondering what caused losing and worry about whether it’ll happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing can be acquired for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most typical cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also called “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved in a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a baby to develop normally it is crucial that it have exactly the right level of chromosome material; missing or extra material during conception or in an embryo or fetus can cause a female to either not get pregnant, miscarry, or have a baby with a chromosome syndrome such as Down syndrome.

pregnancy Over 50% of most first trimester miscarriages are due to chromosome abnormalities. This number may be closer to 75% or higher for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common could it be?

Miscarriage is far more common than a lot of people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The opportunity of experiencing a miscarriage also increases as a mother ages.

Nearly all women who experience a miscarriage go on to have a healthy pregnancy and never miscarry again. However, some women appear to be more susceptible to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this can be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas in the past the miscarriage would have were just a unique period. Another reason may be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many different types of testing that you can do on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), probably the most useful type of test to perform is really a chromosome analysis. A chromosome analysis (also called chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason for the pregnancy loss.

The most common approach to chromosome analysis is called karyotyping. Newer methods include advanced technologies such as for example microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For that reason requirement, tissue that is passed at home is often unable to be tested with this particular method. About 20% or more of miscarriage samples neglect to grow and thus no results are available. Additionally, karyotyping struggles to tell the difference between cells from mom (maternal cells) and cells from the fetus. In case a normal female result is available, it may be the right result for the fetus or it might be maternal cell contamination (MCC) in which the result actually comes from testing the mother’s cells within the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually have a few weeks to months another from the laboratory.

Microarray testing is a new kind of genetic testing done on miscarriage samples; both most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also able to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you’re more likely to receive results and the results are typically returned faster when microarray testing can be used. Additionally, some laboratories are collecting a sample of the mother’s blood at the same time the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

In case a chromosome abnormality is identified, the sort of abnormality found can be assessed to help answer the question: “Will this happen to me again?”. Quite often, chromosome abnormalities in an embryo or fetus are not inherited and have a low possiblity to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your physician to do further studies to research the possibility of an underlying genetic or chromosome problem in your loved ones that predisposes you to have miscarriages.

Furthermore, if a chromosome abnormality is identified it can prevent the need for other, sometimes quite costly, studies your physician might consider to investigate the cause of the miscarriage.

Lastly, knowing the explanation for a pregnancy loss might help a couple of start the emotional healing up process, moving at night question of “Why did this happen to me?”.

Chromosome testing can be especially important for patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason for the miscarriages and allow their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their likelihood of having an effective healthy pregnancy.

Written By JeromyDelea