Apply These Secret Techniques To Improve Pregnancy Loss And Chromosome Testing For Miscarriages

JeromyDelea 27 Mar , 2021 0 Comments Uncategorized

Although most couples are blissfully unacquainted with the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. If you have suffered a pregnancy loss or are in the process of experiencing a miscarriage, you could be wondering what caused losing and worry about whether it will happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What type of genetic testing can be acquired for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most common cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is important that it have the right quantity of chromosome material; missing or extra material at the time of conception or in an embryo or fetus could cause a woman to either not become pregnant, miscarry, or have a child with a chromosome syndrome such as for example Down syndrome.

Over 50% of most first trimester miscarriages are due to chromosome abnormalities. This number could be closer to 75% or higher for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common could it be?

Miscarriage is a lot more common than most people think. Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The opportunity of having a miscarriage also increases as a mother gets older.

Nearly all women who experience a miscarriage go on to have a healthy pregnancy and never miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this can be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas in past times the miscarriage would have appeared to be just an unusual period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many types of testing that you can do on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), the most useful type of test to perform is really a chromosome analysis. A chromosome analysis (also called chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common method of chromosome analysis is called karyotyping. Newer methods include advanced technologies such as for example microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For this reason requirement, tissue that’s passed at home is frequently unable to be tested with this particular method. About 20% or more of miscarriage samples fail to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from the mother (maternal cells) and cells from the fetus. If a normal female result is available, it may be the right result for the fetus or it might be maternal cell contamination (MCC) in which the result actually comes from testing the mother’s cells within the pregnancy tissue instead of the fetal cells. MCC appears to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually have a few weeks to months to come back from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also in a position to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you are more prone to receive results and the results are usually returned faster when microarray testing can be used. Additionally, some laboratories are collecting an example of the mother’s blood as well the miscarriage tissue is delivered to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

If a chromosome abnormality is identified, the type of abnormality found can be assessed to help answer fully the question: “Will this eventually me again?”. Most of the time, chromosome abnormalities within an embryo or fetus are not inherited and have a low chance to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your physician to do further studies to investigate the chance of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, in case a chromosome abnormality is identified it could prevent the dependence on other, sometimes quite costly, studies your physician might consider to investigate the cause of the miscarriage.

pregnancy loss Lastly, knowing the explanation for a pregnancy loss might help a couple of start the emotional healing up process, moving past the question of “Why did this happen to me?”.

Chromosome testing could be especially very important to patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason for the miscarriages and invite their doctor to pursue other types of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their chances of having an effective healthy pregnancy.

Written By JeromyDelea