Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

JeromyDelea 27 Mar , 2021 0 Comments Uncategorized

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is in fact quite common, with 10-25% of recognized pregnancies ending in miscarriage. Assuming you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you might be wondering what caused the loss and worry about whether it will happen again. This article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing can be acquired for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most typical cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a child to develop normally it is important that it have the right level of chromosome material; missing or extra material at the time of conception or in an embryo or fetus can cause a female to either not get pregnant, miscarry, or have a baby with a chromosome syndrome such as for example Down syndrome.

Over 50% of most first trimester miscarriages are caused by chromosome abnormalities. This number could be closer to 75% or higher for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is far more common than a lot of people think. Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The opportunity of experiencing a miscarriage also increases as a mother ages.

Most women who experience a miscarriage go on to get a healthy pregnancy and never miscarry again. However, some women seem to be more susceptible to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage appears to be increasing. One reason for this can be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas in past times the miscarriage would have were just an unusual period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually refers to many types of testing that you can do on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), the most useful type of test to perform is really a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are due to aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common approach to chromosome analysis is named karyotyping. Newer methods include advanced technologies such as for example microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For this reason requirement, tissue that is passed at home is frequently unable to be tested with this particular method. About 20% or more of miscarriage samples fail to grow and thus no results are available. Additionally, karyotyping struggles to tell the difference between cells from mom (maternal cells) and cells from the fetus. In case a normal female result is found, it may be the correct result for the fetus or it may be maternal cell contamination (MCC) where the result actually originates from testing the mother’s cells within the pregnancy tissue instead of the fetal cells. MCC appears to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months another from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be in a position to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you are more prone to receive results and the outcomes are typically returned faster when microarray testing can be used. Additionally, some laboratories are collecting a sample of the mother’s blood simultaneously the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

If a chromosome abnormality is identified, the type of abnormality found can be assessed to help answer the question: “Will this eventually me again?”. infant loss Most of the time, chromosome abnormalities within an embryo or fetus aren’t inherited and have a low possiblity to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your physician to do further studies to investigate the chance of an underlying genetic or chromosome problem in your loved ones that predisposes one to have miscarriages.

Furthermore, in case a chromosome abnormality is identified it could prevent the dependence on other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the explanation for a pregnancy loss might help a couple start the emotional healing up process, moving at night question of “Why did this happen to me?”.

Chromosome testing can be especially very important to patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason for the miscarriages and allow their doctor to pursue other types of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their chances of having an effective healthy pregnancy.

Written By JeromyDelea